Holographic polymer dispersed liquid crystals (HPDLCs) containing triallyl isocyanurate monomer

The morphology and corresponding performance of holographic polymer dispersed liquid crystals (HPDLCs) based on thiol-ene polymer are dependent on a number of factors including the gel point conversion of the polymer, polymerization kinetics, and extent of liquid crystal (LC) phase separation. Previous research of HPDLC reflection gratings made from thiol-allyl ether polymer indicates that increasing polymerization rate in systems with moderate gel point conversion can improve diffraction efficiency (DE). This work examines HPDLC reflection gratings that contain the ene monomer triallyl isocyanurate (TATATO). In HPDLCs, thiol-TATATO polymerization is two times faster than the thiol-ene polymerization of triallyl ether. By substituting TATATO for triallyl ether, the LC droplet size within HPDLC reflection gratings decreases from 100 nm to 25 nm. The dramatic reduction in LC droplet size for thiol-TATATO HPDLCs increases baseline transmission from 55% in thiol-triallyl ether HPDLCs to 90% at 450 nm. Unfortunately, the DE of thiol-TATATO HPDLCs is only approximately 10% due to poorly defined lamellae in the grating morphology. As determined with real-time IR (RTIR) spectroscopy, thiol-TATATO HPDLCs have significantly faster LC demixing kinetics in comparison to thiol-allyl ether HPDLCs. During holographic photopolymerization, the increased rate of LC demixing causes formation of LC droplets throughout the grating. The low DE of thiol-TATATO HPDLCs can be improved by mixing TATATO and allyl ether monomer. The morphology of ternary thiol-ene HPDLC formulations containing TATATO and allyl ether has a well-defined grating structure due to increased LC solubility in the system, an average LC droplet size of 50 nm, and baseline transmission of nearly 85% at 450 nm.     

Memory loss resulting from fornix and septal damage: Impaired supra-span recall but preserved recognition over a 24-hour delay.

Despite increasing evidence that the fornix is important for memory, uncertainty remains about the exact nature of subsequent impairments arising from damage to this tract. This uncertainty is often created by pathology in additional brain structures. The present study involved a young man, DN, who had almost complete bilateral loss of the rostral columns of the fornix and much of the surrounding septum in the left hemisphere following the surgical removal of a cavernous angioma. Quantitative MRI analyses of structure size, normalized to intracranial volume, showed no difference in any of the additional brain regions measured, apart from those areas removed to expose the tumor. DN showed a marked, stable anterograde memory impairment that was still present 4 years postsurgery. In contrast, DN performed within normal levels on most tests of recognition memory. This sparing was most striking when given a 24-hr delay between study and test of the Warrington Recognition Memory Test. This recall/recognition dissociation provides further evidence for neuroanatomical divisions within recognition memory processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Generalization of therapeutic changes in agoraphobia: The role of perceived self-efficacy.

Investigated the extent and mechanisms of therapeutic generalization across distinct areas of agoraphobic dysfunction. Twenty-seven severe agoraphobics were each given performance-based treatment for some phobic areas while leaving their other phobias untreated. Behavioral tests revealed that (a) the treated phobias improved significantly more than the untreated (transfer) phobias, (b) the transfer phobias improved significantly more than control phobias, and (c) the transfer benefits were highly variable within and between subjects. Analyses of possible cognitive mechanisms revealed that perceived self-efficacy accurately predicted treatment and transfer effects even when alternative factors such as previous behavior, anticipated anxiety, anticipated panic, perceived danger, and subjective anxiety were held constant. In contrast, these alternative factors lost most or all predictive value when self-efficacy was held constant. Agoraphobia thus appears to be neither a unitary entity nor a mere collection of independent phobias, but a complexly patterned problem governed largely by self-perceptions of coping efficacy. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Peelfit: An Integrated Computer Program for Pharmacokinetic Analysis

An Integrated program PEELFIT is reported for the Apple IIe microcomputer, which performs pharmacokinetic analysis for intravenous and first order absorption (oral or intramuscular) data. PEELFIT, written in basic language, uses plasma concentration and time for input. Upon the user's choice, it carries out non-linear regression on the data for curve fitting, according to a one or two compartment model. the curve fitting can be done with three weighting schemes. Parameters of the plasma concentration equations are obtained from the regression analysis and further, these are employed to calculate the relevant pharmacokinetic parameters. Finally, the percentage of dose absorbed (absorbable fraction) is calculated as a function of time. various known data were analysed with PEELFIT and the results obtained confirmed its accuracy.     

Quantitative Estimation and Separation of Doxycycline Hc1 and its Related Products

An HPLC method is presented for the separation of doxycycline HC1 from its analogs. The method, employing on line U.V. detection allows separation and quantitative estimation of doxycycline HC1 when its analogs are present upto 1% w/w. By this method doxycycline HC1 powder and tablets were analysed     

Factors influencing the reporting of father-child sexual abuse: Study of licensed practicing psychologists.

Several studies have indicated that high proportions of practicing psychologists fail to report cases of suspected child sexual abuse despite their knowledge of mandatory reporting laws. We surveyed 279 practicing psychologists from two states, using a set of controlled vignettes. Results indicate that clinicians' decisions to report suspected sexual child abuse are affected by the accused father's admission or denial of abuse and by the clinician's expectation of what effect reporting would have on continued therapy. Results are discussed in the context of previous research and state mandatory reporting laws. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A conceptual framework for examining adolescent identity, media influence, and social development.

The adolescent identity, media, and sociocognitive schema (AIMSS) framework offers a theoretical understanding of adolescent consumption and cognitive processing of media entertainment. Review and integration of mass communication theory, developmental theory, and ecological theory serves as the conceptual foundation. The framework outlines linkages between media exposure and adolescent development, in particular adolescent identity formation and social competence. A key contribution of the model is consideration of the positive and negative aspects of adolescent cognition and behavioral functioning. The present article offers several recommendations for testing the utility of the AIMSS framework. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mutations of CLCN5 in Japanese children with idiopathic low molecular weight proteinuria, hypercalciuria and nephrocalcinosis

We designed the present study to examine the cross-sectional relation between age-related lens opacities and vitamin C supplement use over a 10-12-y period before assessment of lens status in women without diagnosed cataract or diabetes. This design avoids biased measurement of nutrient intake that results when knowledge of lens opacities influences nutrition-related behavior or its reporting. The participants were 247 Boston-area women aged 56-71 y selected from the Nurses' Health Study cohort with oversampling of women with high or low vitamin C intakes. Lens opacities were graded with the Lens Opacification Classification System II. Use of vitamin C supplements for > or = 10 y (n = 26) was associated with a 77% lower prevalence of early lens opacities (odds ratio: 0.23; 95% CI: 0.09, 0.60) at any lens site and a 83% lower prevalence of moderate lens opacities (odds ratio: 0.17; 95% CI: 0.03, 0.85) at any lens site compared with women who did not use vitamin C supplements (n = 141) after adjustment for age and other potentially confounding variables. Women who consumed vitamin C supplements for < 10 y showed no evidence of a reduced prevalence of early opacities. These data, together with data from earlier experimental and epidemiologic studies, suggest that long-term consumption of vitamin C supplements may substantially reduce the development of age-related lens opacities.     

Nicotinic and muscarinic cholinergic receptor binding in the human hippocampal formation during development and aging

High-affinity nicotine, alpha-bungarotoxin (alpha BT) and muscarinic receptor binding was measured in the human hippocampal formation in a series of 57 cases aged between 24 weeks gestation and 100 years. Changes in nicotine receptor binding during development and aging were more striking than differences in alpha BT and muscarinic binding. Nicotine binding was higher at the late foetal stage than at any other subsequent time in all areas investigated. In the hippocampus a fall in binding then occurred within the first six months of life, with little or no subsequent fall during aging, whereas in the entorhinal cortex and the presubiculum the major loss of nicotine binding occurred after the fourth decade. alpha BT binding was significantly elevated in the CA 1 region, but in no other region of the hippocampus, in the late foetus, and there was also a fall in alpha BT binding in the entorhinal cortex during aging from the second decade. The modest changes in total muscarinic binding, which appeared to reflect those in M1 and M3 + 4 rather than M2 binding, were a rise in the entorhinal cortex between the foetal stage and childhood and a tendency for receptors to fall with age in the hippocampus and subicular complex. These findings implicate mechanisms controlling the expression of nicotinic receptors to a greater extent than muscarinic receptors in postnatal development and aging in the human hippocampus.